Zacharopoulos, Ioannis (University of Manchester), Tao, Min (University of Manchester), Theodoropoulos, Constantinos (Univ of Manchester)

Modelling and MPC of the bioproduction of succinic acid in a continuous bioreactor with immobilised cells

Scheduled for presentation during the Regular Session "Tribute to Antonio A. Alonso I" (TuS1M), Tuesday, July 26, 2022, 10:00−10:20, Lassonde M-2103

IFAC Workshop on Thermodynamic Foundations of Mathematical Systems Theory, July 24-27, 2022 , Montreal, Canada

This information is tentative and subject to change. Compiled on April 19, 2024

Abstract

Accurate bioprocess models are essential to significantly reduce experimental trial and error and to construct robust optimisation and control strategies (Theodoropoulos and Sun (2019)). Here we present a novel continuous bioreactor with immobilised cells in a packed-bed formation for the efficient bioproduction of succinic acid. We test the predictive capabilities of our model and we use it in an optimal MPC formulation employing a 2-step model reduction process to address the inherent complexity and large-scale characteristics of our model for real-time applications.